On November 2, 2021, the Centers for Medicare & Medicaid Services (CMS) finalized the calendar year (CY) 2022 Medicare Physician Fee Schedule (MPFS). This brief summarizes key changes in the fee schedule from CY 2021, along with other payment reductions that physicians could face in 2022. Absent Congressional action, the average 2022 Medicare reimbursement for physicians will decrease by approximately 9.62% from 2021 levels. Wakely will be watching closely in the coming weeks for any action by Congress that impacts Medicare reimbursement.